Dr Koon-Pong Wong BEng(Hons), PhD, MACS, SrMIEEE Staff Researcher Department of Molecular & Medical Pharmacology David Geffen School of Medicine University of California, Los Angeles 10833 Le Conte Avenue Los Angeles, CA 90095   Office: B2-085E CHS Telephone: 310-825-7985 Fascimile: 310-825-4517 E-mail: kpwong@mednet.ucla.edu

Biography [CV]

Dr. Wong is a member of the IFAC Technical Committee on Modelling and Control of Biomedical Systems (TC 8.2) since 2003 and was the Executive Secretary between 2003 and 2008. He is a member of Australian Computer Society and IEEE. He was awarded the 1996-1998 Postgraduate Tuition Scholarship at the Hong Kong Polytechnic University for his doctoral work on development of mathematical modeling and signal processing techniques for noninvasive functional imaging using PET. He received the 2007 IEEE Medical Imaging Conference Travel Award for his work on quantification of amyloid imaging using [¹⁸F]FDDNP with PET and head movement correction for amyloid imaging in human. He was a Guest Editor of the special issue on modeling and control in biomedical systems of the Control Engineering Practice in 2005.

Research Interests

• Modeling and kinetic analysis of PET, SPECT, and microPET data
• Biomedical imaging (PET/SPECT/MR/CT) with application to neurology and oncology
• Development of quantitative analysis methodologies and their automation
• Medical image analysis--functional segmentation, compression, registration, head movement correction

Projects

• Kinetic analysis of [¹⁸F]FDDNP with PET for Alzheimer's disease
• Head movement correction for dynamic human brain imaging
• Noninvasive estimation of input function for PET, SPECT, and microPET studies
• Development of plasma input function models
• Kinetic analysis of [¹²³I]iodo-A-85380 with SPECT for nAChRs receptor binding
• Functional/dynamic image segmentation
• Spatiotemporal image data compression
• Registration of PET/MR/CT data
• Development of fast parametric imaging algorithms

Courses Taught

• Computer Tomography: Theory and Applications (Graduate Level) [UCLA]: Winter 2010, 2011
• Logic Design (using VHDL) (Undergraduate Level) [HKPU]: Semester 2, 2003
• Computer Programming and Basic Software Engineering (Undergraduate Level) [HKPU]: Semester 2, 2002; Semester 1, 2003
• Information Technology in Biomedicine (Graduate Level) [USyd]: Autumn 2000, Winter 2001
• Biomedical Instrumentation and Measurement (Graduate Level) [HKPU]: Spring 1998

Selected Publications

• Sha W, Ye H, Iwamoto KS, Wong K-P, Wilks M, Stout D, McBride W, and Huang S-C. Factors affecting tumor ¹⁸F-FDG uptake in longitudinal mouse PET studies. European Journal of Nuclear Medicine and Molecular Imaging Research, 3:51, 2013. [PMCID: PMC3718724]
• Smid LM, Kepe V, Vinters HV, Bresjanac M, Toyokuni T, Satyamurthy N, Wong K-P, Huang S-C, Silverman DHS, Miller K, Small GW, and Barrio JR. A post mortem 3-D brain hemisphere cortical tau and amyloid-beta pathology mapping and quantification as a validation method of neuropathology imaging. Journal of Alzheimer's Disease, 36(2):261-274, 2013. [PMCID: PMC3688653]
• Wong K-P, Kepe V, Dahlbom M, Satyamurthy N, Small GW, Barrio JR, and Huang S-C. Comparative evaluation of Logan and relative-equilibrium graphical methods for parametric imaging of dynamic [¹⁸F]FDDNP PET determinations. NeuroImage, 60(1):241-251, 2012. [NIHMS ID: NIHMS345868]
• Kreissl MC, Stout DB, Wong K-P, Wu H-M, Caglayan E, Ladno W, Zhang X, Prior JO, Reiners C, Huang S-C, and Schelbert HR. Influence of dietary state and insulin on myocardial, skeletal muscle and brain [¹⁸F]-fluorodeoxyglucose kinetics in mice. European Journal of Nuclear Medicine and Molecular Imaging Research, 1:8, 2011. [PMCID: PMC3155201]
• Wong K-P, Sha W, Zhang X, and Huang S-C. Effects of administration route, dietary condition, and blood glucose level on kinetics and uptake of ¹⁸F-FDG in mice. Journal of Nuclear Medicine, 52(5):800-807, 2011. [PMCID: PMC3086987]
• Olafsen T, Young SG, Davies BSJ, Kenanova VE, Voss C, Young G, Wong, K-P, Barnes RH II, Tu Y, Weinstein MW, Nobumori C, Huang S-C, Goldberg IJ, Bensadoun A, Wu AM, and Fong LG. Unexpected expression pattern for glycosylphosphatidylinositol-anchored HDL-binding protein 1 (GPIHBP1) in mouse tissues revealed by positron emission tomography scanning. Journal of Biological Chemistry, 285(50):39239-39248, 2010. [PMCID: PMC2998116]
• Ishikawa T, Kumar IP, Machado HB, Wong K-P, Kusewitt D, Huang S-C, Fischer SM, and Herschman HR. Positron emission tomography imaging of DMBA/TPA mouse skin multi-step tumorigenesis. Molecular Oncology, 4(2):119-125, 2010. [PMCID: PMC2838935]
• Wardak M, Wong K-P, Shao W, Dahlbom M, Kepe V, Small GW, Barrio JR, and Huang S-C. Movement correction method for human brain PET images: Application to quantitative analysis of dynamic ¹⁸F-FDDNP scans. Journal of Nuclear Medicine, 51(2):210-218, 2010. [PMCID: PMC2929579]
• Wong, K-P, Wardak M, Shao W, Dahlbom M, Kepe V, Liu J, Satyamurthy N, Small GW, Barrio JR, and Huang S-C. Quantitative analysis of [¹⁸F]FDDNP PET data using subcortical white matter as reference region. European Journal of Nuclear Medicine and Molecular Imaging, 37(3):575-588, 2010. [PMCID: PMC2822232]
• Wong K-P, Huang S-C, Fulham MJ. Evaluation of an input function model that incorporates the injection schedule in FDG-PET studies. IEEE Nuclear Science Symposium and Medical Imaging Conference. San Diego, California, 2006; 2086-2090.
• Choi H-C, Chen S, Feng D, Wong K-P. Fast parametric imaging algorithm for dual-input biomedical system parameter estimation. Comput Method Programs Biomed. 2006; 81:49-55.
• Wong K-P. Medical image segmentation: Methods and applications in functional imaging. In: Handbook of Biomedical Image Analysis - Volume 2: Segmentation Models Part B (Edited by Suri JS, Wilson DL, Laxminarayan S), Chapter 3, pp. 111-182, Kluwer Academic/Plenum Publishers, USA, 2005.
• Wong K-P. Quantitative functional imaging with positron emission tomography: Principles and instrumentation. In: Handbook of Biomedical Image Analysis - Volume 1: Segmentation Models Part A (Edited by Suri JS, Wilson DL, Laxminarayan S), Chapter 2, pp. 57-116, Kluwer Academic/Plenum Publishers, USA, 2005.
• Wen L, Eberl S, Wong K-P, Feng D, Bai J. Effect of reconstruction and filtering on kinetic parameter estimation bias and reliability for dynamic SPECT: A simulation study. IEEE Trans Nucl Sci. 2005; 52:69-78.
• Wong K-P, Meikle SR, Feng D, Fulham MJ. Estimation of input function and kinetic parameters using simulated annealing: Application in a flow model. IEEE Trans Nucl Sci. 2002; 49:707-713.
• Wong K-P, Feng D, Meikle SR, Fulham MJ. Segmentation of dynamic PET images using cluster analysis. IEEE Trans Nucl Sci. 2002; 49:200-207.
• Li X, Feng D, Wong K-P. A general algorithm for optimal sampling schedule design in nuclear medicine imaging. Comput Methods Programs Biomed. 2001; 65:45-59.
• Wong K-P, Feng D, Meikle SR, Fulham MJ. Simultaneous estimation of physiological parameters and the input function - In vivo PET data. IEEE Trans Inform Technol Biomed. 2001; 5:67-76.
• Wong K-P, Feng D, Siu W-C. Generalized linear least squares algorithm for non-uniformly sampled biomedical system identification with possible repeated eigenvalues. Comput Methods Programs Biomed. 1998; 57:167-177.
• Feng D, Wong K-P, Wu C-M, Siu W-C. A technique for extracting physiological parameters and the required input function simultaneously from PET image measurements: Theory and simulation study. IEEE Trans Inform Technol Biomed. 1997; 1:243-254.